The study of the effect of high explosives on structures is important for the design of new protective elements or assessment of existing capacity. In this context, detonation tests of TNT charges will be executed observing the blast effects on structural thin sheets made from A36 steel. Before conducting these tests, it is necessary to predict the blast stand-off distance and steel sheet thickness that will be necessary to optimize the blast effects. To achieve this goal, a series of finite element method (FEM) simulations were performed in Abaqus® software, varying the stand-off distances and thicknesses. The automation of these simulations was performed through a Python macro compatible with the FEM software.